| Name | Type | Class | Level | Locations |
| Samuel Howard | 41 | Port Royal | ||
| Sandra Williams | Quest NPC | 41 | Bridgetown | |
| Sanson Marroqui | Quest NPC | Sisal | ||
| Santiago Cafra | Quest NPC | Villa Hermosa | ||
| Sara Langewech | Quest NPC | Iguana | ||
| Sara Tarrega | Quest NPC | Grand Turk | ||
| Sarah Cox | 41 | Port Royal | ||
| Sean Selitrennikoff | Quest NPC | Pirate | Black Point | |
| Segunda Isabell | Carlos Harbour | |||
| Serafina el Tigre | Quest NPC | Sisal | ||
| Seraphine Forquin | Quest NPC | Pirate | 11 | Tampa |
| Servant | 5 | A Man Of Wealth and Taste House | ||
| Seymour Metcalf | Les Hattes | |||
| Shaw Blundstone | Quest NPC | A Mission | ||
| Sherlocke Rower | Quest NPC | 6 | Georgetown | |
| Shiela Barylett | 41 | Port Royal | ||
| Sigurd Langstraat | Quest NPC | Harbour Island | ||
| Silva | Quest NPC | Maracaibo | ||
| Silvestre Salvador | Quest NPC | 3 | Vera Cruz | |
| Silvia Duveau | Quest NPC | St. Rose's Bay | ||
| Simon Berri | Quest NPC | Naval Officer | 1 | Charlesfort |
| Simon Boxall | Quest NPC | 6 | Georgetown | |
| Simon Desautels | Quest NPC | 36 | Roseau | |
| Simon Lorenzo | Quest Target | 16 | ||
| Smuggler Underboss | (Smugglers Union) | Pointe-a-Pitre | ||
| Society Registrar | 1 | Marsh Harbour, Vera Cruz, Port Royal, Pointe-a-Pitre | ||
| Solomon Pritt | Quest NPC | Pirate | 1 | Marsh Harbour |
| Solomon Putt | NPC | 1 | Treasure Bay | |
| Suero Carral | Quest NPC | Cape de Vela | ||
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