| Name | Type | Class | Level | Locations |
| East India Company Auditor | 41 | Port Royal | ||
| Ebenezer Dignum | Quest NPC | 5 | Marsh Harbour | |
| Edwin Codwell | (British Royal Society) | Pointe-a-Pitre | ||
| Elise Souvigne | Fort Caroline | |||
| Eloisa | Quest NPC | Maracaibo | ||
| Eloise Dudemaine | Quest NPC | Freetrader | 11 | Tampa |
| Emerald Knott | Quest NPC | A Mission | ||
| Emil Delavant | Quest NPC (Magistrate) | Naval Officer | 11 | Tampa |
| Emilie du Chatelet | Pointe-a-Pitre | |||
| Enoch Stickley | Quest NPC | 6 | Georgetown | |
| Erick Bickers | 41 | Port Royal | ||
| Escobar Gonzalez | Quest NPC | Cape de Vela | ||
| Esteban Carral | Quest NPC | Campeche | ||
| European Trader Greenfield | Quest NPC | 6 | Rosignol | |
| European Trader Lagarenne | Pointe-a-Pitre | |||
| European Trader Medhurst | Quest NPC | 41 | Port Royal | |
| European Trader Ynfante | Quest NPC | Freetrader | 6 | Barilla |
| Eva Maria Racoso | Quest NPC | Marsh Harbour | ||
| Evans McCreedy | 41 | Port Royal | ||
| Eve Dalmas | Quest NPC | 26 | Vieux Fort | |
| Exchequer | Quest NPC | Port Royal, San Juan | ||
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